Postdoctoral Scientist - Circadian Rhythm & Metastasis Group

Postdoctoral position

Application deadline: 07 Nov 2025

Institute: Cancer Research UK Scotland Institute
Country: United Kingdom
More information: https://www.crukscotlandinstitute.ac.uk/careers/postdoctoral-fellows/2105-postdoc-zd-nov25.html

Postdoctoral scientist – The role of the circadian rhythm on metastasis
Salary: from £37,000 to £44,852 subject to experience, plus relocation allowance and visa costs if required.
Contract term: Fixed up to 6 years, subject to successful review at Year 3.

We are seeking an enthusiastic Postdoctoral Research Scientist with a strong passion for unravelling the complexities of metastasis to work on an ambitious project fully funded by the UKRI Future Leaders Fellowship. The project is to investigate the intricate relationship between metastasis and the circadian rhythm. Our research builds upon our recent publication, which demonstrates that breast cancer cells spread during sleep (https://www.nature.com/articles/s41586-022-04875-y).

The successful candidate will analyse a range of breast cancer mouse models available at the CRUK Scotland Institute and cancer patient samples to uncover the mechanisms through which the circadian rhythm regulates the metastatic spread of Circulating Tumour Cells (CTCs) and identify molecular targets for therapeutic intervention. This will involve a combination of cutting-edge microfluidics and robotic technologies, along with spatial transcriptomics, single-cell analysis methods, next generation sequencing, CRISPR screens and imaging techniques.

To be considered for this position you will have successfully (or nearly) completed a PhD in a relevant field. Expertise in working with mouse models is essential and proficiency in R or Python for omic data analysis is desirable. While prior research experience with CTCs or circadian rhythm would be advantageous, it is not mandatory, as appropriate training will be provided. The ideal candidate will be meticulous, capable of independent thinking, and possess strong planning and prioritisation skills. You should work proactively and meet deadlines effectively. An excellent record of publications is also expected.

Closing Date: 07 November, but we may contact promising candidates on a rolling basis, so please apply as soon as you are ready.

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