Introduction

Cancer is a systemic disease, where factors produced by tumours alter the function of peripheral tissues with profound consequences that we are only beginning to understand.  

Tumours alter the interface with the immune system to evade immune surveillance. The function of the liver, muscle and adipose tissue is altered in cancer producing profound metabolic and inflammatory changes that affect the whole body. Brain function is also altered in cancer leading to loss of appetite and inducing a feeling of sickness. Collectively these systemic alterations produce the wasting syndrome known as cancer cachexia that leads to the death of most patients with advanced cancer.  

Exploring the underlying mechanisms behind these systemic effects holds promise for the development of more effective treatments. 

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Target audience

Those with an interest in cancer biology, inter-organ communication, the role of cytokines, chemokines, and hormones in cancer; and cancer-induced changes in behaviour and metabolism. 

Topics to be covered:

• How cancer alters the immune system
• Cancer induced systemic metabolic reprogramming of the host
• Mechanisms of niche formation in tumour metastasis
• Cancer cachexia
• How cancer alters the brain and behaviour including anorexia
• New opportunities for therapeutic intervention

Scientific Programme Committee

• Eileen White (Chair), Rutgers Cancer Institute of New Jersey, US
• Karen Vousden, Sir Francis Crick Institute, UK
• Marcus Goncalves, Weill Cornell Medicine, US
• Tobias Janowitz, Cold Spring Harbor Laboratory, US

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