Application deadline: 25 Sep 2022
Institute: Cancer Research UK Manchester Institute
Country: United Kingdom
More information: https://www.cruk.manchester.ac.uk/recruitment/candidate/searchvacancies
POSTDOCTORAL SCIENTIST – STEM CELL BIOLOGY
Salary in the range of £31,604 – £41,929 (dependent upon qualifications and experience)
Job Ref: MI/22/62
Duration: Fixed term for 3 years
About the role:
Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by a block in differentiation and an accumulation of immature myeloid cells. Cytotoxic therapy has been the standard of care over the last 30 years for AMLs. Unfortunately, more often than not, it fails to cure the patient (5 years survival rate lower than 30%). Therefore, there is a pressing need for the development of more specific and efficient therapies. Bulk and single cell RNA sequencing have empowered researchers to quantify the global gene expression of populations and single cells to further understand the development, maintenance and treatments of cancers. The main aims of this project are to use state of the art single cell RNA-seq and bioinformatics to define the cellular hierarchy in MOZ and MLL gene rearranged leukaemia, to determine how these different cellular compartments are affected by drug/compound treatments and to identify genes critical for the maintenance of the most immature cell populations.
You should have a PhD in molecular or cell biology (or a relevant field). Relevant experience in haematopoiesis or leukaemia working with cellular or in vivo models is required. Essential qualities should include independent thinking, ability to work in a team and good communication skills, all of which are needed to efficiently work in a multidisciplinary team.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
How to apply?:
To apply for this position please visit our website:
Informal enquiries should be directed to Georges Lacaud firstname.lastname@example.org
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