A post-doctoral research fellowship is available at AUSL – IRCCS di Reggio Emilia to characterize the role of long non-coding RNAs (lncRNAs) in regulating cytotoxic activity of Natural Killer cells. This is a full-time position available for one year, starting September 2022, with possibility of renewal.
The activity of Natural Killer (NK) cells is pivotal to maintain the immune surveillance on many type of cancer, including lung cancer. In oncology, NK cells hold an high potential both as cell therapy and as therapeutic targets. Although it is known the role of long non coding RNAs (lncRNAs) in regulating the differentiation and the activation of different immune populations, their function in NK cells biology is still unclear. In the laboratory, they observed that inhibitors of Bromodomain and Extraterminal domain proteins (BETi) increase the cytotoxic activity of NK cells against lung cancer cell lines and primary 3D cultures. Strikingly, 15% of genes deregulated by BETi treatment in NK cells are lncRNAs. Among these, the lab identified a panel of 13 lncRNAs, which show an expression profile associated to key genes for NK cells function. The main goal of this project is to define the role of these lncRNAs in regulating cytotoxic activity and response to BETi in NK cells. To this end, they will use co-culture experiments between NK cells and lung cancer cell lines or patients-derived primary 3D cultures. The lab will use single cell RNA-sequencing to assess the expression of lncRNAs in immune populations. The mechanism of action of selected lncRNAs will be characterized through transcriptomic, molecular biology and biochemistry approaches. We expect that the results of this project will lead to clarify important aspects of NK cells biology, useful for their implementation in anti-cancer therapy.
The Laboratory of Translational Research (https://www.linkedin.com/company/translational-research-laboratory/mycompany/) focuses on basic and translational research in oncology. It comprises 20 researchers, including young and senior scientists, technicians and group leaders. The activity of the Laboratory covers the areas of genomics, bioinformatics, functional genomics and cancer biology. The group led by dr.ssa Valentina Sancisi (https://www.linkedin.com/in/valentina-sancisi-a7259670/) focuses on lung cancer biology, functional genomics and new therapeutic approaches. Dr.ssa Valentina Sancisi is supported by both internal funding and external funding from AIRC (Associazione Italiana Ricerca contro il Cancro).
The AUSL – IRCCS is a Comprehensive Cancer Center, part of the Italian Network of excellence centers in oncology. The AUSL – IRCCS is committed to deliver advanced healthcare services along with the development of high quality basic and translational research. It is located in Reggio Emilia, a small but vibrant town in the north of Italy, at 20 minutes from Bologna and 40 minutes from Milan.
Applications and enquiries about the position should be sent to email@example.com and should include a CV with a list of publications, a cover letter and contact information for at least two references. Closing date July 31 2022.
Application deadline: 31 Jul 2022
Application deadline: 31 Jul 2022
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