Please visit the website: https://nbidere.wixsite.com/soap, @LabSoap
The “Signaling in Oncogenesis, Angiogenesis and Permeability” (SOAP) team is
interested in deciphering how tumor cells pirate basic signaling pathways to sustain
their survival and unlimited proliferation, as well as the way in which they interact
within their environment. Fundamental signaling mechanisms are explored with a
specific emphasis on deleterious remodeling of the vascular network associated to
We developed a specific expertise in the characterization of intracellular signaling
pathways with a focus on brain tumors. More specifically, we have identified key
factors released in the tumor microenvironment involved in tumor/endothelial
bidirectional interactions. How this is translated into endothelial plasticity in the
course of tumor progression warrants further investigation.
Our project combines high throughput unbiased screens (proteomic, genomic and
chemical) with state-of-the-art biochemistry and cell biology (2D/3D cell models,
super-resolution), as well as integrated models (mouse models and clinical samples)
to explore intracellular signaling and cell communication.
We anticipate that our results will increase our knowledge on basic signaling
mechanisms involved in tumor initiation, progression and resistance, and may help
the design of new strategies to face devastating human cancers.
The EACR is grateful for the continued support of its Industry Partners: