Listed times are in Central European Time (CET)

REGISTRATION (light refreshments will be served at 12:00)

CONFERENCE WELCOME

SESSION 1

Chair: Leila Akkari

OPENING KEYNOTE LECTURE

Ashani Weeraratna Johns Hopkins, Baltimore, USA

'A Complex TIME: how the tumor immune microenvironment governs tumor progression'

Q&A 13:40 - 13:55

Neta Erez Tel Aviv University, Tel Aviv, Israel

'Stromal and Immune Plasticity Shape the Metastatic Microenvironment'

Q&A 14:15 - 14:25

Sebastian Igelmann KuLeuven-VIB, Belgium

Proffered Paper 1: 'Age-accumulated senescent cells fuel melanoma metastasis growth via NK cell inhibition'

Q&A 14:35 - 14:40

EXHIBITOR INTRODUCTIONS

Led by members of the Scientific Programme Committee

COFFEE BREAK, EXHIBITION AND SOLO TRAVELLER MEET-UP

Daniela Quail McGill University, Montreal, Canada

'Exploiting myeloid-driven inflammation in cancer progression'

Q&A 15:40 - 15:50

Erik Sahai Francis Crick Institute, London, UK

‘Modeling Tumor-Stroma Boundaries’

Q&A 16:10 - 16:20

POSTER SPOTLIGHTS

Led by members of the Scientific Programme Committee

NETWORKING QUIZ

WELCOME RECEPTION

POSTER DISCUSSION SESSION 1

Led by members of the Scientific Programme Committee

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING WITH COFFEE & BISCUITS

INDUSTRY SPOTLIGHT - Cell Signaling Technology

Flora Guarnotta Cell Signaling Technology

'Spatial Analysis of Tumor Microenvironments via SignalStar® Multiplex IHC'

SESSION 2

Chair: Erik Sahai

Yardena Samuels Weizmann Institute, Rehovot, Israel

'The various layers of intratumor heterogeneity and their impact on tumor immunity'

Q&A 09:20 - 09:30

Merav Cohen Tel Aviv University, Sackler Faculty of Medicine, Israel

Proffered Paper 2: 'Single cell transcriptomics of efferocytosis identifies a pro-angiogenic tumor associate macrophage state in melanoma'

Q&A 09:40 - 09:45

Mikael Pittet Agora, Lausanne, Switzerland

'Myeloid cells in cancer'

Q&A 10:05 - 10:15

Andrea Schietinger MSKCC, New York, USA

'Tumor-specific CD8 T cell differentiation and dysfunction'

Q&A 10:35 - 10:45

COFFEE BREAK & EXHIBITION

Mara Sherman Memorial Sloan Kettering Cancer Center, New York, USA

'Mapping cellular hierarchies in the pancreatic tumor microenvironment'

Q&A 11:35 - 11:45

Greta Mattavelli University Hospital Würzburg, Germany

Proffered Paper 3: 'Tumor-draining lymph node stroma supports pre-metastatic niche formation by promoting immunosuppressive cellular networks'

Q&A 11:55 - 12:00

POSTER SPOTLIGHTS

Led by members of the Scientific Programme Committee

LUNCH

POSTER DISCUSSION SESSION 2

Led by members of the Scientific Programme Committee

SESSION 3

Chair: Johanna Joyce

The EMBO Young Investigator Lecture

Leila Akkari Netherlands Cancer Institute, Amsterdam, Netherlands

'Leveraging Myeloid Cell Diversity in Cancer- A Matter of Plasticity and Metabolism'

Q&A 15:05 - 15:15

Charles Earnshaw CRUK Manchester Institute, UK

Proffered Paper 4: 'Glucocorticoids inhibit the GARP/TGF-β axis triggering immune-dependent melanoma control'

Q&A 15:25 - 15:30

Nicolae Ciobu Zubenco Columbia University, USA

Proffered Paper 5: 'Lipid desaturation as a metabolic checkpoint for T cell immunity suppression in liver cancer'

Q&A 15:40 - 15:45

Anna Obenauf IMP, Austria

'Unlocking immunity: Decoding and reprogramming the immune-evasive tumor microenvironment'

Q&A 16:05 - 16:15

COFFEE BREAK & EXHIBITION

Ilaria Malanchi Francis Crick Institute, London, UK

'Shaped by Cancer: Neutrophil Systemic Rewiring and Metastatic Support'

Q&A 17:05 - 17:15

Jacco van Rheenen NKI, Amsterdam, Netherlands

'Timing Matters: How Hormonal Rhythms Govern Mutation Clearance, Cancer Initiation, and Treatment Response'

Q&A 17:35-17:45

PANEL DISCUSSION - Meet the Expert

Ashani Weeraratna (Johns Hopkins, USA), Daniela Quail (McGill University, Canada), Direna Alonso-Curbelo (IRB Barcelona, Spain), Jacco van Rheenen (NKI, Netherlands)

CONFERENCE DINNER (optional ticketed event)

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING WITH COFFEE & BISCUITS

INDUSTRY SPOTLIGHT - Moleculent

Jeroen Aerts Moleculent

'Deciphering cell-cell interactions at scale'

SESSION 4

Chair: Neta Erez

The EMBO Keynote Lecture

Johanna Joyce University of Lausanne, Lausanne, Switzerland

'Unraveling the Complexity of Cancer Ecosystems'

Q&A 09:20 - 09:30

Dinorah Friedmann-Morvinski TAU, Tel Aviv, Israel

'Overcoming the immunosuppressive Microenvironment to enhance CAR T cell therapy in brain tumors'

Q&A 09:50 - 10:00

Sarai Martinez Pacheco Centro Nacional de Investigaciones Oncológicas (CNIO), Spain

Proffered Paper 6: 'TET2-Dependent Immunosuppressive Programs Drive Ovarian Cancer Progression'

Q&A 10:10 - 10:15

COFFEE BREAK & EXHIBITION

Direna Alonso-Curbelo IRB Barcelona, Spain

'When Tissues Decide: Epigenetic Plasticity at the Crossroads of Inflammation and Cancer'

Q&A 11:05 - 11:15

CLOSING KEYNOTE LECTURE

Frank Winkler DKFZ, Heidelberg, Germany

'Neural influences on brain tumors: from fundamental insights to new therapies'

Q&A 11:45 - 12:00

SUMMARY & CLOSE

DEPART