Listed times are in Central European Time (CET)

WELCOME TO DAY ONE

Session 1

Session Chair: Chiara Ambrogio

The EMBO Keynote Lecture

Andreas Trumpp HI-STEM, Germany

'From stem cells in leukemia to neurons in pancreatic cancer'

Q&A 12:25-12:35

Janne Lehtiö Karolinska Institut, Sweden

'Proteogenomics for systems level analysis of genotype - molecular phenotype connections in cancer'

Q&A 12:55-13:05

Coralie Dessauges Harvard Medical School, USA

Proffered Paper 1: 'Prolonged BRAF targeted therapy leads to co-existing lineage states with distinct collective behaviors'

Q&A 13:15-13:20

Livia Perfetto Sapienza University of Rome, Italy

Proffered Paper 2: 'PatientProfiler, a novel tool to derive signalling-based biomarkers'

Q&A 13:30-13:35

REFRESHMENT BREAK

Session 2

Session Chair: Jukka Westermarck

Flash Talks Session 1

4 top-scoring abstracts presented as 3-minute flash talks

Zuzana Storchová RPTU, Germany

'Mechanisms Mitigating Cellular Stresses Triggered by Aneuploidy'

Q&A 14:25-14:35

Phuong-Hien Nguyen University of Cologne, Germany

Proffered Paper 3: 'Macrophage LYN signaling drives tumor progression and metabolic vulnerability in non-small cell lung cancer'

Q&A 14:45-14:50

REFRESHMENT BREAK

Flash Talks Session 2

4 top-scoring abstracts presented as 3-minute flash talks

Sabrina Digiovanni University of Turin, Italy

Proffered Paper 4: 'IRAK1 controls chemo-immuno-resistance in NSCLC'

Q&A 15:30-15:35

Debanjan Singha Roy Tel Aviv University, Israel

Proffered Paper 5: 'Drug Persistence to Resistance Evolution Analysis in Human Leukemia Reveals Diverse Leukemia-Initiating Cell Phenotypes'

Q&A 15:45-15:50

Arjun Raj Perelman School of Medicine, USA

'Building cellular memories as a mechanism of therapy resistance in melanoma'

Q&A 16:10-16:20

SUMMARY AND CLOSE

Listed times are in Central European Time (CET)

WELCOME TO DAY TWO

Session 3

Session Chair: Yaara Oren

Stephan Vagner Institut Curie, France

'The RNA binding activity of the BRAF kinase'

Q&A 12:25-12:35

Adrian Saurin University of Dundee, UK

'Understanding resistance to cell cycle-based chemotherapies'

Q&A 12:55-13:05

Jose L Orgaz Bueno Faculty of Health Sciences / University Carlos III of Madrid, Spain

Proffered Paper 6: 'Dedifferentiating melanomas rewire to actomyosin signaling during early adaptation to MAPK pathway inhibition'

Q&A 13:15-13:20

Gaia Giannitti Università degli Studi di Milano, Italy

Proffered Paper 7: 'Extracellular vesicles from adipocytes facilitate melanoma progression by enhancing mitochondrial bioenergetics'

Q&A 13:30-13:35

REFRESHMENT BREAK

Session 4

Session Chair: Venkatram Yellapragada

Flash Talks Session 3

4 top-scoring abstracts presented as 3-minute flash talks

Mihkel Örd Cancer Research UK Cambridge Institute, UK

Proffered Paper 8: 'Identifying cancer dependencies in peptide-interacting protein pocket'

Q&A 14:15-14:20

Lior Lobel Bar-Ilan University, Israel

'Gut Microbial Activity Modulates Cancer Immunotherapy'

Q&A 14:40-14:50

REFRESHMENT BREAK

Flash Talks Session 4

4 top-scoring abstracts presented as 3-minute flash talks

Melissa Junttila ORIC Pharmaceuticals Inc, USA

'PRC2 inhibition enhances sensitivity to androgen receptor pathway inhibitors by restricting adaptation of prostate tumors and inducing a luminal cell state'

Q&A 15:40-15:50

Guillermo de Cárcer Instituto de Investigaciones Biomédicas Sols-Morreale, Spain

Proffered Paper 9: 'Osmotic stress as a modulator of the response to microtubule-based therapies'

Q&A 16:00-16:05

DISCUSSION SESSION

Open Forum with SPC members Jukka Westermarck, Yaara Oren and Chiara Ambrogio

SUMMARY AND CLOSE