Listed times are in Central European Time (CET)

REGISTRATION & WELCOME LUNCH

Light refreshments will be served at 12:00

CONFERENCE WELCOME

SESSION 1: Genetics & Genomics

Chair: Aurélie Ernst

Opening Keynote

David Pellman Harvard University & DFCI, USA

'Mechanisms driving the rapid evolution of genomes'

Q&A: 13:40 - 13:55

EMBO Young Investigator Lecture

Aurélie Ernst DKFZ, Germany

'Genomic instability in cancer: From retrotransposon activity to p53-driven replication stress'

Q&A: 14:15 - 14:25

Husayn Pallikonda Francis Crick Institute, UK

Proffered Paper 1: 'Mechanistic diversity of chromosome 3p loss defines distinct chromosomal instability phenotypes in clear cell renal cell carcinoma'

Q&A: 14:35 - 14:40

EXHIBITOR INTRODUCTIONS

COFFEE BREAK, EXHIBITION & SOLO TRAVELLER MEET-UP

Nicholas McGranahan UCL, UK

'Order or chaos: deciphering lung cancer genome evolution'

Q&A: 15:35 - 15:45

Serena Nik-Zainal (Pre-recorded presentation) University of Cambridge, UK

'Recent advances in indel and structural variation signatures'

Molecular Oncology: Call for Content

POSTER SPOTLIGHTS

Poster 01: Thomas van Ravesteyn (Netherlands) 'Deterministic karyotype evolution in precancerous colonic organoids'

Poster 20: Katyayni Ganesan (Germany) 'Paired whole-genome and single-nucleus multiome profiling of pancreatic ductal adenocarcinoma across primary and metastatic sites'

Poster 40: Federica Camin (Italy) 'Cytoplasmic flooding of micronuclei disrupts nucleotide homeostasis and promotes genome instability'

SPEED NETWORKING RECEPTION

Invited speakers and the conference organizers will each host a table of participants, covering different topics for discussion.

WELCOME RECEPTION

POSTER DISCUSSION SESSION 1

Led by members of the Scientific Programme Committee

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING

INDUSTRY SPOTLIGHT - De Gruyter Brill

Izabela Żarczyńska De Gruyter Brill

'Academic publishing in the era of AI - navigating the ethical boundaries'

SESSION 2: Cell Biology

Chair: Renata Basto

Renata Basto Institut Curie, France

'Mechanical constraints regulate embryonic stem cell mitosis in the developing brain'

Q&A: 09:20 - 09:30

Varvara-Rigina Louma Charité – University Medicine Berlin, Germany

Proffered Paper 2: 'ecDNA Reintegration Reshapes Local Chromatin and Gene Expression'

Q&A: 09:40 - 09:45

Ofer Shoshani Weizmann Institute of Science, Israel

'​​Double-strand DNA break location dictates chromosomal fate and mechanisms of gene amplification'

Q&A: 10:05 - 10:15

COFFEE BREAK & EXHIBITION

Daniele Fachinetti Institut Curie, France

'Causes and Consequences of Centromeric Instability'

Q&A: 11:05 - 11:15

John Maciejowski MSKCC, USA

'Innate immune defenses in cancer'

Q&A: 11:35 - 11:45

Pierre Foidart University of Liege and CHU of Liège, Belgium

Proffered Paper 3: 'Whole-genome doubling drives immune evasion by silencing antigen presentation'

Q&A: 11:55 - 12:00

POSTER SPOTLIGHTS

Poster 60: Tobias Thomas Schmidt (USA) 'Escape from replicative crisis and immortalization precedes complex genome evolution'

Poster 75: Nikoleta Pateraki (Germany) 'A novel framework to dissect chromosome-specific dependencies upon errors in mitosis'

Poster 90: Tal Ben-Yishay (Israel) 'The evolutionary landscape and functional consequences of chromothripsis in human cancer cell lines'

LUNCH

POSTER DISCUSSION SESSION 2

Led by members of the Scientific Programme Committee

SESSION 3: Technologies & Models

Chair: Florian Markowetz

Florian Markowetz CRUK Cambridge Institute, UK

'Measuring ongoing CIN from single-cell genomes'

Q&A: 14:50 - 15:00

Lukas Frank Princess Maxima Center, Netherlands

Proffered Paper 4: 'Multimodal imaging reveals how gene context shapes transcription and spatial organization of extrachromosomal DNA in cancer cells'

Q&A: 15:10 - 15:15

Sjors Middelkamp Princess Máxima Center, Netherlands

Proffered Paper 5: 'Pervasive but non-compounding aneuploidy in normal human colon tissue'

Q&A: 15:25 - 15:30

Jan Korbel EMBL, Germany

'Learning about chromosomal instability processes from integrating imaging and genomics'

Q&A: 15:50 - 16:00

COFFEE BREAK & EXHIBITION

Sarah McClelland Barts Cancer Institute, Queen Mary University of London, UK

'Trials and tribulations on the journey to identify drivers of cancer genome evolution'

Q&A: 16:50 - 17:00

Susanne Lens UMC Utrecht, Netherlands

'Trisomy 7 establishes just-right WNT signalling in APC-mutant colorectal cancer'

Q&A: 17:20 - 17:30

PANEL DISCUSSION - Career journeys decoded: From academia, industry, publishing and beyond

Moderated by Renata Basto

Scheduled to end at 18:30

CONFERENCE DINNER (optional ticketed event)

Listed times are in Central European Time (CET)

EARLY POSTER VIEWING

SESSION 4: Oncology & Clinical Opportunities

Chair: Uri Ben-David

EMBO Young Investigator Lecture

Uri Ben-David Tel Aviv University, Israel

'Targeting aneuploidy: From tumor evolution to therapeutic opportunities'

Q&A: 09:20 - 09:30

Beth Weaver McArdle Laboratory for Cancer Research, USA

'Leveraging chromosomal crisis to optimize anti-cancer therapy'

Q&A: 09:50 - 10:00

Selene Mallia AUSL Reggio Emilia, Italy

Proffered Paper 6: 'Chromatin-guided spatial separation of replication and transcription prevents genomic crisis in ALCL'

Q&A: 10:10 - 10:15

COFFEE BREAK & EXHIBITION

Samuel Bakhoum Geisel School of Medicine at Dartmouth / Volastra Therapeutics, USA

'Chromosomal instability as a therapeutic target'

Q&A: 11:05 - 11:15

Closing Keynote

TBC

Q&A: 11:45 - 12:00

SUMMARY, AWARDS & CLOSE

DEPART