Listed times are in Central European Time (CET)

WELCOME TO DAY ONE

Chair: Cédric Blanpain

Mark Dawson Peter MacCallum Cancer Centre, Australia

'Genetic and non-genetic mechanisms of clonal dominance and therapeutic resistance in cancer'

Q&A 13:25-13:35

Direna Alonso-Curbelo IRB Barcelona, Spain

'Epigenetic plasticity at the crossroads of inflammation and pancreatic tumorigenesis'

Q&A 13:55-14:05

Christopher Hanley University of Southampton, UK

Proffered Paper 1: 'TP53 Inactivation and Microenvironmental Cues Coordinate Lineage Plasticity and Therapy Resistance in Lung Adenocarcinoma'

Q&A 14:15-14:20

FLASH TALKS 1

A selection of high-scoring abstracts presented as 3 minute flash talks.

REFRESHMENT BREAK

Chair: Dana Pe'er

Raphael Rodriguez Institut Curie, France

'Chemical control of cell adaptation'

Q&A 15:10-15:20

Sven Größl German Cancer Research Center, Germany

Proffered Paper 2: 'Acidosis orchestrates adaptations of energy metabolism in tumors'

Q&A 15:30-15:35

Marco Fantuz Veneto Institute of Molecular Medicine, Italy

Proffered Paper 3: 'Multi-omic single nuclei profiling of murine pancreas at homeostasis'

Q&A 15:45-15:50

REFRESHMENT BREAK

Adrienne A. Boire Memorial Sloan Kettering Cancer Centre, USA

'Metabolic Reprogramming of Metastases in the Central Nervous System'

Q&A: 16:25-16:35

FLASH TALKS 2

A selection of high-scoring abstracts presented as 3 minute flash talks.

SUMMARY AND CLOSE

Listed times are in Central European Time (CET)

WELCOME TO DAY TWO

Chair: Eduard Batlle

Ilaria Malanchi Francis Crick Institute, UK

'Emergency granulopoiesis and cancer progression'

Q&A 13:25-13:35

Cassandra Burdziak Memorial Sloan Kettering Cancer Centre, USA

'Decoding orthogonal axes of plasticity in prostate cancer progression'

Q&A 13:55-14:05

Tancredi Massimo Pentimalli Max Delbruck Center, Germany

Proffered Paper 4: 'Spatiotemporal dynamics of tumor microenvironment remodeling'

Q&A 14:15-14:20

FLASH TALKS 3

A selection of high-scoring abstracts presented as 3 minute flash talks.

REFRESHMENT BREAK

Chair: Chris Marine

Julie Pannequin Institut de Génomique Fonctionnelle (IGF), France

Proffered Paper 5: 'Impact of 5-Fluorouracil (5-FU) on tumor plasticity'

Q&A 15:00-15:05

The EMBO Keynote Lecture

Eduard Batlle IRB Barcelona, Spain

'Plasticity, therapy resistance and immune evasion in metastatic colorectal cancer'

Q&A 15:25-15:35

Lars Custers ETH Zürich, Switzerland

Proffered Paper 6: 'Malignant differentiation dynamics drive chemotherapeutic escape in colorectal cancer'

Q&A: 15:45-15:50

REFRESHMENT BREAK

Frederic de Sauvage Genentech, USA

'Tumor cell plasticity in colon cancer'

Q&A 16:25-16:35

FLASH TALKS 4

A selection of high-scoring abstracts presented as 3 minute flash talks.

DISCUSSION SESSION

Chris Marine, Cedric Blanpain, Dana Pe'er, Eduard Batlle

'Examining the importance of phenotypic plasticity as a driver of cancer evolution'

SUMMARY AND CLOSE